Posttraumatic stress disorder (PTSD) is a disorder that can develop after exposure to a terrifying event or ordeal in which grave physical harm occurred or was threatened. Traumatic events that may trigger PTSD include violent personal assaults, natural or human-caused disasters, accidents, or military combat. In DSM-IV (1994), PTSD was classified as an anxiety disorder. DSM-5 (2013) has moved PTSD out of the anxiety disorders section into a newly created section, “Trauma- and stressor- related disorders.”
Resick PA, Bovin MJ, Calloway AL, Dick AM, King MW, Mitchell KS, Suvak MK, Wells SY, Stirman SW, Wolf EJ.J Trauma Stress. 2012 Jun;25(3):241-51. AbstractComplex posttraumatic stress disorder (CPTSD) has been proposed as a diagnosis for capturing the diverse clusters of symptoms observed in survivors of prolonged trauma that are outside the current definition of […]
Searcy CP, Bobadilla L, Gordon WA, Jacques S, Elliott L.Mil Med. 2012 Jun;177(6):649-54. AbstractPreventing posttraumatic stress disorder (PTSD) could have a significant positive impact on military readiness and quality of life. Few studies have examined whether pharmacological agents may prevent PTSD, and there has not been a systematic and critical review of these studies in […]
Wentworth BA, Stein MB, Redwine LS, Xue Y, Taub PR, Clopton P, Nayak KR, Maisel AS.Cardiol Rev. 2012 Jun 20. [Epub ahead of print] AbstractAn increasing body of evidence reported in the literature indicates a possible role for post-traumatic stress disorder (PTSD) as a cause for cardiovascular disease (CVD). However, mechanistic evidence on the progression […]
Patel R, Spreng RN, Shin LM, Girard TA.Neurosci Biobehav Rev. 2012 Jul 2. [Epub ahead of print] AbstractOver the past two decades a relatively large number of studies have investigated the functional neuroanatomy of posttraumatic stress disorder (PTSD). However, findings are often inconsistent, thus challenging traditional neurocircuitry models of PTSD. As evidence mounts that cognition […]
Holdorff B.Hist Psychiatry. 2011 Dec;22(88 Pt 4):465-76. Abstract. The concept of traumatic neurosis conceived by Hermann Oppenheim (1858-1919) located post-traumatic nervous symptoms between hysteria and neurasthenia, considering them a consequence of physical reactions to fright and a cause of molecular tissue changes. As early as 1890, his concept was criticized at an international congress in […]
Andero R, Ressler KJ.Genes Brain Behav. 2012 Apr 24. doi: 10.1111/j.1601-183X.2012.00801.x. [Epub ahead of print] Abstract. Brain-derived neurotrophic factor (BDNF) is the most studied neurotrophin involved in synaptic plasticity processes that are required for long-term learning and memory. Specifically, BDNF gene expression and activation of its high-affinity TrkB receptor are necessary in the amygdala, hippocampus […]
Boscarino JA, Erlich PM, Hoffman SN, Zhang X.Neuropsychiatr Dis Treat. 2012;8:131-9. AbstractOBJECTIVE: The study aim was to assess the cumulative burden of polymorphisms located within four genetic loci previously associated with posttraumatic stress disorder (PTSD) among outpatients at risk for PTSD. METHODS: Diagnostic interviews were completed and DNA samples collected among 412 pain patients to […]
Sekiguchi A, Sugiura M, Taki Y, Kotozaki Y, Nouchi R, Takeuchi H, Araki T, Hanawa S, Nakagawa S, Miyauchi CM, Sakuma A, Kawashima R.Mol Psychiatry. 2012 May 22. doi: 10.1038/mp.2012.51. [Epub ahead of print] AbstractMany survivors of severe disasters, even those without posttraumatic stress disorder (PTSD), need psychological support. To understand the pathogenesis of PTSD […]
Golier JA, Caramanica K, Demaria R, Yehuda R.Depress Res Treat. 2012:393251. AbstractBackground. We obtained pilot data to examine the clinical and neuroendocrine effects of short-term mifepristone treatment in male veterans with PTSD. Methods. Eight male veterans with military-related PTSD completed a randomized, double-blind trial of one week of treatment with mifepristone (600 mg/day) or placebo. […]
Vermetten E, Lanius RA.Handb Clin Neurol. 2012;106:291-342. AbstractThree decades of posttraumatic stress disorder (PTSD) research have placed it well on the map. PTSD is a young disorder that started being properly understood only from 1980 with incorporation in DSM-III, in which it was acknowledged that exposure to traumatic events can lead to long-term psychopathology. This […]
