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The CRF(1) receptor antagonist SSR125543 attenuates long-term cognitive deficit induced by acute inescapable stress in mice, independently from the hypothalamic pituitary adrenal axis

Philbert J, Pichat P, Palme R, Belzung C, Griebel G.Pharmacol Biochem Behav. 2012 May 31. [Epub ahead of print] Abstract. The selective antagonist at the CRF(1) receptor, SSR125543, has been shown to produce anxiolytic-like effects in a number of animal models. The aim of the present study was to verify whether these effects are mediated […]

The fight for ‘traumatic neurosis’, 1889-1916: Hermann Oppenheim and his opponents in Berlin

Holdorff B.Hist Psychiatry. 2011 Dec;22(88 Pt 4):465-76. Abstract. The concept of traumatic neurosis conceived by Hermann Oppenheim (1858-1919) located post-traumatic nervous symptoms between hysteria and neurasthenia, considering them a consequence of physical reactions to fright and a cause of molecular tissue changes. As early as 1890, his concept was criticized at an international congress in […]

Fear extinction and BDNF: Translating animal models of PTSD to the clinic

Andero R, Ressler KJ.Genes Brain Behav. 2012 Apr 24. doi: 10.1111/j.1601-183X.2012.00801.x. [Epub ahead of print] Abstract. Brain-derived neurotrophic factor (BDNF) is the most studied neurotrophin involved in synaptic plasticity processes that are required for long-term learning and memory. Specifically, BDNF gene expression and activation of its high-affinity TrkB receptor are necessary in the amygdala, hippocampus […]

Higher FKBP5, COMT, CHRNA5, and CRHR1 allele burdens are associated with PTSD and interact with trauma exposure: implications for neuropsychiatric research and treatment

Boscarino JA, Erlich PM, Hoffman SN, Zhang X.Neuropsychiatr Dis Treat. 2012;8:131-9. AbstractOBJECTIVE: The study aim was to assess the cumulative burden of polymorphisms located within four genetic loci previously associated with posttraumatic stress disorder (PTSD) among outpatients at risk for PTSD. METHODS: Diagnostic interviews were completed and DNA samples collected among 412 pain patients to […]

Killing in combat may be independently associated with suicidal ideation

Maguen S, Metzler TJ, Bosch J, Marmar CR, Knight SJ, Neylan TC.Depress Anxiety. 2012 Apr 13. doi: 10.1002/da.21954. [Epub ahead of print] BACKGROUND: The United States military has lost more troops to suicide than to combat for the second year in a row and better understanding combat-related risk factors for suicide is critical. We examined […]

A glass full of optimism: Enrichment effects on cognitive bias in a rat model of depression

Richter SH, Schick A, Hoyer C, Lankisch K, Gass P, Vollmayr B.Cogn Affect Behav Neurosci. 2012 May 29. [Epub ahead of print] AbstractInvestigations of cognitive biases in animals are conceptually and translationally valuable because they contribute to animal welfare research and help to extend and refine our understanding of human emotional disorders, where biased information […]

Trends in alcohol-related deaths in the EU countries in 1980-2003

Innamorati M, Pompili M, Martinotti G, Serafini G, Amore M, Lester D, Girardi P, Janiri L.Int J Soc Psychiatry. 2012 Apr 16. [Epub ahead of print] AbstractAIMS: To explore temporal trends since 1980 in alcohol-related death for people resident in the European Union (EU) and to examine differences between EU members admitted prior to 2004 […]

Guidelines for the pharmacological treatment of anxiety disorders, obsessive-compulsive disorder and posttraumatic stress disorder in primary care

Bandelow B, Sher L, Bunevicius R, Hollander E, Kasper S, Zohar J, Möller HJ; WFSBP Task Force on Mental Disorders in Primary Care; WFSBP Task Force on Anxiety Disorders, OCD and PTSD.Int J Psychiatry Clin Pract. 2012 Jun;16(2):77-84. AbstractObjective. Anxiety disorders are frequently under-diagnosed conditions in primary care, although they can be managed effectively by […]

Brain structural changes as vulnerability factors and acquired signs of post-earthquake stress

Sekiguchi A, Sugiura M, Taki Y, Kotozaki Y, Nouchi R, Takeuchi H, Araki T, Hanawa S, Nakagawa S, Miyauchi CM, Sakuma A, Kawashima R.Mol Psychiatry. 2012 May 22. doi: 10.1038/mp.2012.51. [Epub ahead of print] AbstractMany survivors of severe disasters, even those without posttraumatic stress disorder (PTSD), need psychological support. To understand the pathogenesis of PTSD […]

A pilot study of mifepristone in combat-related PTSD

Golier JA, Caramanica K, Demaria R, Yehuda R.Depress Res Treat. 2012:393251. AbstractBackground. We obtained pilot data to examine the clinical and neuroendocrine effects of short-term mifepristone treatment in male veterans with PTSD. Methods. Eight male veterans with military-related PTSD completed a randomized, double-blind trial of one week of treatment with mifepristone (600 mg/day) or placebo. […]

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