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Epigenetic modifications associated with suicide and common mood and anxiety disorders: a systematic review of the literature

El-Sayed AM, Halossim MR, Galea S, Koenen KC.Biol Mood Anxiety Disord. 2012 Jun 14;2(1):10. [Epub ahead of print] AbstractABSTRACT: Epigenetic modifications are those reversible, mitotically heritable alterations in genomic expression that occur independent of changes in gene sequence. Epigenetic studies have the potential to improve our understanding of the etiology of mood and anxiety disorders […]

Stoicism and Sensation Seeking: Male Vulnerabilities for the Acquired Capability for Suicide

Witte TK, Gordon KH, Smith PN, Van Orden KA.J Res Pers. 2012 Aug 1;46(4):384-392. AbstractOur aim was to investigate two personality traits (i.e., stoicism and sensation seeking) that may account for well-established gender differences in suicide, within the framework of the interpersonal theory of suicide. This theory proposes that acquired capability for suicide, a construct […]

Reasons for suicide attempts in a clinical sample of active duty soldiers

Bryan CJ, Rudd MD, Wertenberger E.J Affect Disord. 2012 Aug 1. [Epub ahead of print] AbstractBACKGROUND: Self-reported reasons for suicide attempts were examined in a sample of active duty soldiers who had attempted suicide using a functional approach that classifies suicidal behaviors into four primary functions of reinforcement: automatic negative (AN-R; to reduce aversive internal […]

The Association between Pathological Internet Use and Comorbid Psychopathology: A Systematic Review

Carli V, Durkee T, Wasserman D, Hadlaczky G, Despalins R, Kramarz E, Wasserman C, Sarchiapone M, Hoven CW, Brunner R, Kaess M.Psychopathology. 2012 Jul 31. [Epub ahead of print] AbstractBackground: Pathological Internet use (PIU) has been conceptualized as an impulse-control disorder that shares characteristics with behavioral addiction. Research has indicated a potential link between PIU […]

Testosterone levels in suicide attempters with bipolar disorder

Sher L, Grunebaum MF, Sullivan GM, Burke AK, Cooper TB, Mann JJ, Oquendo MA.J Psychiatr Res. 2012 Jul 31. [Epub ahead of print] AbstractOBJECTIVE: The best known neurobehavioral effects of testosterone are on sexual function and aggression. However, testosterone and other androgens may be involved in the pathophysiology of mood disorders and suicidal behavior. This […]

Evaluation of a third-location decompression program for Canadian Forces members returning from Afghanistan

Garber BG, Zamorski MA.Mil Med. 2012 Apr;177(4):397-403. AbstractBACKGROUND: Service members returning from combat can experience difficulty adapting to home life. To help ease this transition, the Canadian Forces provides a Third-location Decompression (TLD) program in Cyprus to members returning from deployment to Afghanistan. METHODS: The 5-day program consists of individual free time, structured recreational activities, […]

Health outcomes associated with military deployment: mild traumatic brain injury, blast, trauma, and combat associations in the Florida National Guard

Vanderploeg RD, Belanger HG, Horner RD, Spehard AM, Powell-Cope G, Luther SL, Scott SG.Arch Phys Med Rehabil. 2012 Jun 13. [Epub ahead of print] AbstractOBJECTIVE: To determine the association between specific military deployment experiences and immediate and longer- term physical and mental health effects, as well as examine the effects of multiple deployment-related traumatic brain […]

Do child abuse and maltreatment increase risk of schizophrenia?

Sideli L, Mule A, La Barbera D, Murray RM.Psychiatry Investig. 2012 Jun;9(2):87-99. INTRODUCTION: Although childhood abuse is a recognised risk factor for depression, post-traumatic stress disorder, and substance misuse, its role in the aetiology of psychotic disorder remained controversial. This is in part because the putative effect of childhood trauma on psychosis has been mostly […]

Post-traumatic stress disorder: A fast track to premature cardiovascular disease?

Wentworth BA, Stein MB, Redwine LS, Xue Y, Taub PR, Clopton P, Nayak KR, Maisel AS.Cardiol Rev. 2012 Jun 20. [Epub ahead of print] AbstractAn increasing body of evidence reported in the literature indicates a possible role for post-traumatic stress disorder (PTSD) as a cause for cardiovascular disease (CVD). However, mechanistic evidence on the progression […]

Lentivirus-mediated expression of Drosophila melanogaster deoxyribonucleoside kinase driven by the hTERT promoter combined with gemcitabine: A potential strategy for cancer therapy

Zhang N, Zhao L, Ma S, Gu M, Zheng X.Int J Mol Med. 2012 Jun 14. doi: 10.3892/ijmm.2012.1033. [Epub ahead of print] AbstractIn contrast to other enzymes, Drosophila melanogaster deoxyribonucleoside kinase (Dm-dNK) has a broad substrate specificity and high catalytic rate when transferred in human cells. This makes it a promising therapeutic agent when administered […]

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