Mood Disorders

Enhancing management of depression and type 1 diabetes in adolescents and young adults

Hillege S, Beale B, McMaster R.Arch Psychiatr Nurs. 2011 Dec;25(6):e57-67 AbstractAnxiety, depression, and eating disorders are higher in adolescents and young adults with diabetes than in their unaffected counterparts worldwide. This descriptive qualitative research paper, using secondary analysis, described the experiences of adolescents and young adults living with depression and Type 1 diabetes. The study […]

Can bipolar disorder be viewed as a multi-system inflammatory disease?

Leboyer M, Soreca I, Scott J, Frye M, Henry C, Tamouza R, Kupfer DJ.J Affect Disord. 2012 Apr 10. [Epub ahead of print] Abstract.BACKGROUND: Patients with bipolar disorder are known to be at high risk of premature death. Comorbid cardio-vascular diseases are a leading cause of excess mortality, well above the risk associated with suicide. […]

Considerations in the pharmacotherapy of bipolar disorder during and after pregnancy

Sharma V.Curr Drug Saf. 2011 Nov 1;6(5):318-23. AbstractThere are conflicting data on the course of bipolar disorder during pregnancy but childbirth is generally considered a time of high risk for the onset or exacerbation of mood and psychotic episodes in women with bipolar disorder. Despite the increasing use of psychotropic drugs in women with psychiatric […]

Controlled trial of safety and efficacy of bright light therapy vs. negative air ions in patients with bipolar depression

Dauphinais DR, Rosenthal JZ, Terman M, Difebo HM, Tuggle C, Rosenthal NE.Psychiatry Res. 2012 Mar 14. [Epub ahead of print] AbstractTreatment of bipolar disorder often results in patients taking several drugs in attempt to alleviate residual depressive symptoms, which can lead to an accumulation of side effects. New treatments for bipolar depression that do not […]

Synapsin II is involved in the molecular pathway of lithium treatment in bipolar disorder

Cruceanu C, Alda M, Grof P, Rouleau GA, Turecki G.PLoS One. 2012;7(2):e32680. AbstractBipolar disorder (BD) is a debilitating psychiatric condition with a prevalence of 1-2% in the general population that is characterized by severe episodic shifts in mood ranging from depressive to manic episodes. One of the most common treatments is lithium (Li), with successful […]

Antidepressant treatment for acute bipolar depression: an update

Amit BH, Weizman A.Depress Res Treat. 2012;2012:684725. Epub 2012 Jan 27. AbstractWhile studies in the past have focused more on treatment of the manic phase of bipolar disorder (BD), recent findings demonstrate the depressive phase to be at least as debilitating. However, in contrast to unipolar depression, depression in bipolar patients exhibits a varying response […]

The antidepressant hyperforin increases the phosphorylation of CREB and the expression of TrkB in a tissue-specific manner.

Gibon J, Deloulme JC, Chevallier T, Ladevèze E, Abrous DN, Bouron A.Int J Neuropsychopharmacol. 2012 Jan 9:1-10. [Epub ahead of print] AbstractHyperforin is one of the main bioactive compounds that underlie the antidepressant actions of the medicinal plant Hypericum perforatum (St. John’s wort). However, the effects of a chronic hyperforin treatment on brain cells remains […]

Serum brain-derived neurotrophic factor level in relation to illness severity and episode duration in patients with major depression.

Birkenhäger TK, Geldermans S, Van den Broek WW, van Beveren N, Fekkes D.J Psychiatr Res. 2012 Jan 11. [Epub ahead of print] AbstractBACKGROUND: Since there are few data on the possible association between BDNF levels and characteristics of major depression, the present study assesses brain-derived neurotrophic factor (BDNF) levels in three drug-free patient samples, and […]

Treatment of suicide attempters with bipolar disorder: a randomized clinical trial comparing lithium and valproate in the prevention of suicidal behavior

Oquendo MA, Galfalvy HC, Currier D, Grunebaum MF, Sher L, Sullivan GM, Burke AK, Harkavy-Friedman J, Sublette ME, Parsey RV, Mann JJ.Am J Psychiatry 2011 Oct;168(10):1050-6. OBJECTIVE: Bipolar disorder is associated with high risk for suicidal acts. Observational studies suggest a protective effect of lithium against suicidal behavior. However, testing this effect in randomized clinical […]

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