Depression is a mental disorder characterized by low mood accompanied by other symptoms
Leo Sher, M.D. A meta-analysis, “Depression, antidepressants and driving safety” was published in Injury Epidemiology in 2017 (1). The purpose of this study was to review the reported associations of depression and antidepressants with motor vehicle crashes. This paper included epidemiologic studies published in English between January 1995 and October 2015. Retrieved articles were systematically […]
Kiraly DD, Sher L.Int J Adolesc Med Health. 2014 Nov 20. pii: /j/ijamh.ahead-of-print/ijamh-2015-5017/ijamh-2015-5017.xml. doi: 10.1515/ijamh-2015-5017. [Epub ahead of print] Abstract. Here, we publish a report of a previously practicing nurse practitioner who presented to a community hospital with severely depressed mood and neurovegetative symptoms in the context of recent relapse to alcohol and cocaine abuse. […]
Sher L, Oquendo MA, Burke AK, Cooper TB, Mann JJ.J Affect Disord. 2013 Jul 15. pii: S0165-0327(13)00529-6. doi: 10.1016/j.jad.2013.06.049. [Epub ahead of print] AbstractBACKGROUND: The hypothalamic-pituitary-adrenal (HPA) axis is dysfunctional in a subgroup of mood disorders. METHODS: We compared cortisol and adrenocorticotropic hormone (ACTH) responses in major depression and healthy volunteers to the combined dexamethasone […]
Wilhelm S, Boess FG, Hegerl U, Mergl R, Linden M, Schacht A, Schneider E.Expert Opin Drug Saf. 2012 Jun 20. [Epub ahead of print] AbstractObjective: This study questions whether a lower starting dose of duloxetine (DLX) could be beneficial for patients with depression, in terms of tolerability and safety in routine clinical care. Research design […]
Richter SH, Schick A, Hoyer C, Lankisch K, Gass P, Vollmayr B.Cogn Affect Behav Neurosci. 2012 May 29. [Epub ahead of print] AbstractInvestigations of cognitive biases in animals are conceptually and translationally valuable because they contribute to animal welfare research and help to extend and refine our understanding of human emotional disorders, where biased information […]
Rosenbluth M, Macqueen G, McIntyre RS, Beaulieu S, Schaffer A; Canadian Network for Mood and Anxiety Treatments (CANMAT) Task Force.Ann Clin Psychiatry. 2012 Feb;24(1):56-68. AbstractBACKGROUND: The association between mood disorders and personality disorders (PDs) is complicated clinically, conceptually, and neurobiologically. There is a need for recommendations to assist clinicians in treating these frequently encountered patients. […]
Ravera S, Ramaekers JG, de Jong-van den Berg LT, de Gier JJ.Clin Ther. 2012 May 1. [Epub ahead of print] AbstractBACKGROUND: Selective serotonin reuptake inhibitors (SSRIs) are widely used medications to treat several psychiatric diseases and, above all, depression. They seem to be as effective as older antidepressants but have a different adverse effect profile. […]
Hillege S, Beale B, McMaster R.Arch Psychiatr Nurs. 2011 Dec;25(6):e57-67 AbstractAnxiety, depression, and eating disorders are higher in adolescents and young adults with diabetes than in their unaffected counterparts worldwide. This descriptive qualitative research paper, using secondary analysis, described the experiences of adolescents and young adults living with depression and Type 1 diabetes. The study […]
Pompili M, Innamorati M, Rihmer Z, Gonda X, Serafini G, Akiskal H, Amore M, Niolu C, Sher L, Tatarelli R, Perugi G, Girardi P.J Affect Disord. 2011 Dec 16. [Epub ahead of print] Abstract.BACKGROUND: Suicidal behavior is one of the most alarming signs not only in psychiatry, and current major depressive episode is the most […]
Gibon J, Deloulme JC, Chevallier T, Ladevèze E, Abrous DN, Bouron A.Int J Neuropsychopharmacol. 2012 Jan 9:1-10. [Epub ahead of print] AbstractHyperforin is one of the main bioactive compounds that underlie the antidepressant actions of the medicinal plant Hypericum perforatum (St. John’s wort). However, the effects of a chronic hyperforin treatment on brain cells remains […]
