Bipolar disorder, also known as manic depressive disorder, is apsychiatric diagnosis defined by the presence of mania/hypomania anddepression
Sher L, Grunebaum MF, Sullivan GM, Burke AK, Cooper TB, Mann JJ, Oquendo MA.J Affect Disord. 2014 Sep;166:98-102. AbstractBACKGROUND: Considerable evidence suggests that testosterone may play a role in the pathophysiology of mood disorders in females. This is the first prospective study to examine whether blood testosterone levels predict suicide attempts in females with bipolar […]
Gale CR, Batty GD, McIntosh AM, Porteous DJ, Deary IJ, Rasmussen F.Mol Psychiatry. 2013 Feb;18(2):190-4. AbstractAnecdotal and biographical reports have long suggested that bipolar disorder is more common in people with exceptional cognitive or creative ability. Epidemiological evidence for such a link is sparse. We investigated the relationship between intelligence and subsequent risk of hospitalisation […]
Sher L, Grunebaum MF, Sullivan GM, Burke AK, Cooper TB, Mann JJ, Oquendo MA.J Psychiatr Res. 2012 Jul 31. [Epub ahead of print] AbstractOBJECTIVE: The best known neurobehavioral effects of testosterone are on sexual function and aggression. However, testosterone and other androgens may be involved in the pathophysiology of mood disorders and suicidal behavior. This […]
Leboyer M, Soreca I, Scott J, Frye M, Henry C, Tamouza R, Kupfer DJ.J Affect Disord. 2012 Apr 10. [Epub ahead of print] Abstract.BACKGROUND: Patients with bipolar disorder are known to be at high risk of premature death. Comorbid cardio-vascular diseases are a leading cause of excess mortality, well above the risk associated with suicide. […]
Sharma V.Curr Drug Saf. 2011 Nov 1;6(5):318-23. AbstractThere are conflicting data on the course of bipolar disorder during pregnancy but childbirth is generally considered a time of high risk for the onset or exacerbation of mood and psychotic episodes in women with bipolar disorder. Despite the increasing use of psychotropic drugs in women with psychiatric […]
Dauphinais DR, Rosenthal JZ, Terman M, Difebo HM, Tuggle C, Rosenthal NE.Psychiatry Res. 2012 Mar 14. [Epub ahead of print] AbstractTreatment of bipolar disorder often results in patients taking several drugs in attempt to alleviate residual depressive symptoms, which can lead to an accumulation of side effects. New treatments for bipolar depression that do not […]
Cruceanu C, Alda M, Grof P, Rouleau GA, Turecki G.PLoS One. 2012;7(2):e32680. AbstractBipolar disorder (BD) is a debilitating psychiatric condition with a prevalence of 1-2% in the general population that is characterized by severe episodic shifts in mood ranging from depressive to manic episodes. One of the most common treatments is lithium (Li), with successful […]
Amit BH, Weizman A.Depress Res Treat. 2012;2012:684725. Epub 2012 Jan 27. AbstractWhile studies in the past have focused more on treatment of the manic phase of bipolar disorder (BD), recent findings demonstrate the depressive phase to be at least as debilitating. However, in contrast to unipolar depression, depression in bipolar patients exhibits a varying response […]
Oquendo MA, Galfalvy HC, Currier D, Grunebaum MF, Sher L, Sullivan GM, Burke AK, Harkavy-Friedman J, Sublette ME, Parsey RV, Mann JJ.Am J Psychiatry 2011 Oct;168(10):1050-6. OBJECTIVE: Bipolar disorder is associated with high risk for suicidal acts. Observational studies suggest a protective effect of lithium against suicidal behavior. However, testing this effect in randomized clinical […]
Pompili M, Rihmer Z, Akiskal H, Amore M, Gonda X, Innamorati M, Lester D, Perugi G, Serafini G, Telesforo L, Tatarelli R, Girardi P.Compr Psychiatry. 2011 Jun 3. [Epub ahead of print] BACKGROUND:Several studies have demonstrated that bipolar II (BD-II) disorder represents a quite common, distinct form of major mood disorders that should be separated […]
