Alcohol and Drug Abuse

Egli M. Addict Biol. 2005 Dec;10(4):309-19. Evaluating medications in animal laboratory paradigms can reveal whether the compound is effective in an established alcoholism model, at clinically relevant doses and exposure conditions, when administered orally (or transdermally) and without serious limiting side effects. Positive outcomes constitute a possible discovery for relevance to alcoholism and, under favorable […]

Allen GC, West JR, Chen WJ, Earnest DJ. Alcohol Clin Exp Res. 2005 Oct;29(10):1845-52. BACKGROUND: Alcohol exposure during the period of rapid brain development produces structural damage in different brain regions, including the suprachiasmatic nucleus (SCN), that may have permanent neurobehavioral consequences. Thus, this study examined the long-term effects of neonatal alcohol exposure on circadian […]

Sher L. Med Hypotheses. 2005 Dec; 65(6):1010-2. Alcohol use and abuse substantially influence suicide rates. Suicide is a cause of death for a substantial percentage of individuals with alcoholism. However, the results of epidemiological studies of the relation between alcohol use and suicide have been inconsistent. Studies conducted in one nation are not always applicable […]

Ganguli M, Vander Bilt J, Saxton JA, Shen C, Dodge HH. Neurology. 2005 Oct 25;65(8):1210-7. OBJECTIVE: To examine the association between alcohol use and cognitive decline in a longitudinal study of a representative elderly community sample free of dementia at baseline.

Miles DR, Silberg JL, Pickens RW, Eaves LJ. J Stud Alcohol. 2005 Jul;66(4):445-51. OBJECTIVE: Both genetic and common environmental influences contribute to twin associations for substance use; however, twin concordance rates may vary by environmental setting, indicating the presence of genetic-environmental interactions. The present study examined whether measures of family adaptability and cohesion may moderate […]

Sher L, Zalsman G. Alcohol and adolescent suicide. Int J Adolesc Med Health. 2005 Jul-Sep;17(3):197-203. Adolescent suicide is a major public health problem. In this review, the authors discuss different aspects of the relation between alcohol abuse and suicidal behavior in adolescents, including epidemiology, role of family history, comorbidity, gender differences, neurobiology, treatment, and prevention. […]

Sher L. Int J Adolesc Med Health. 2005 Jul-Sep;17(3):291-4. Background: Suicide in adolescents and young adults is a serious medical and social problem. One factor that has been consistently implicated in suicide is alcohol use. This study examined the relation between rates of suicide in 15-24-year-olds and per capita consumption of alcohol beverages in European […]

Doggett C, Burrett S, Osborn D, Osborn D. Cochrane Database Syst Rev. 2005 Oct 19;4:CD004456. BACKGROUND: One potential method of improving outcome for pregnant or postpartum women with a drug or alcohol problem is with home visits.

Moss M. Clin Infect Dis. 2005 Nov 15;41 Suppl 7:S490-7. The annual incidences of severe sepsis in several industrialized nations have recently been reported to be 50-100 cases per 100,000 persons. These numbers exceed the estimated rates for other diseases that hold a heightened public awareness, including breast cancer and acquired immune deficiency syndrome. There […]

Hasin DS, Goodwin RD, Stinson FS, Grant BF. Arch Gen Psychiatry. 2005 Oct;62(10):1097-1106. OBJECTIVE: To present nationally representative data on 12-month and lifetime prevalence, correlates, and comorbidity of DSM-IV major depressive disorder (MDD) among adults in the United States. Design/Setting/ PARTICIPANTS: Face-to-face survey of more than 43 000 adults aged 18 years and older residing […]