Ten years ago

Cerebrospinal fluid monoamine metabolites and lethality of suicide attempts

Leo Sher, M.D. Our research article, “CSF monoamine metabolites and lethality of suicide attempts in depressed patients with alcohol dependence” was published 10 years ago in a 2007 issue of “European Neuropsychopharmacology” (1). Monoaminergic abnormalities have been implicated in the pathophysiology of depression, alcohol use disorder, and suicidal behavior. We examined the relationship of cerebrospinal […]

Regional brain metabolic responses to a serotonergic challenge in major depression with vs. without comorbid alcohol dependence

Leo Sher, M.D. Our research report, “Positron emission tomography study of regional brain metabolic responses to a serotonergic challenge in major depressive disorder with and without comorbid lifetime alcohol dependence” was published in the September 2007 issue of European Neuropsychopharmacology (1). It was the first study comparing the regional glucose metabolic rate (rCMRglu) responses to […]

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