The number of previous depressive episodes and cortisol response to fenfluramine administration

Leo Sher, M.D. Our research report, “The number of previous depressive episodes is positively associated with cortisol response to fenfluramine administration” was published 20 years ago in December 2004 in the Annals of the New York Academy of Sciences (1). Multiple reports document hypothalamic-pituitary-axis (HPA) hyperactivity in depressed patients. Measurement of cortisol levels after ingestion […]

Traumatic brain injury in military veterans

Leo Sher, M.D. A research report, “Traumatic brain injury in U.S. veterans: Prevalence and associations with physical, mental, and cognitive health” has been published in Archives of Physical Medicine and Rehabilitation online ahead of print (1). The authors examined the prevalence of traumatic brain injury (TBI) in the U.S. veteran population, and physical, mental, and […]

International trends in male youth suicidal behavior

Leo Sher, M.D. Our review article, “International trends in male youth suicide and suicidal behavior” has been published in Acta Neuropsychiatrica (1). To our knowledge, our article is the most comprehensive review of global developments in male youth suicidal behavior in the world literature. A summary of our review paper, “International trends in male youth […]

Relationships within combat units and post-deployment suicide risk

Leo Sher, M.D.  My review article, “The impact of relationships within combat units on post-deployment suicide risk” has been published in Behavioral Sciences (1). This is the first review of the relation between interactions within combat entities and post-deployment suicidality in world literature. A summary of my review is below: “Multiple deployment factors may affect […]

Bright light therapy for nonseasonal depression

Leo Sher, M.D. A research paper, “Bright light therapy for nonseasonal depressive disorders: A systematic review and meta-analysis” has been published in JAMA Psychiatry online ahead of print (1). Researchers from Brazil performed a search of publications in the MEDLINE, Embase, and Cochrane databases for randomized clinical trials evaluating bright light therapy effects in patients […]

Objections to suicide among patients with comorbid mood and alcohol use disorders

Leo Sher, M.D. Our research report, “Objections to suicide among depressed patients with alcohol use disorders” was published 15 years ago in the October 2009 issue of the Journal of Affective Disorders (1). In all, 521 mood disordered patients with and without alcohol use disorders were administered a battery of clinical measures including the Scale […]

Suicide ideation in hospitalized psychiatric patients and postdischarge suicide

Leo Sher, M.D. A research report, “A false sense of security: Rapid improvement as a red flag for death by suicide” was published in 2022 in the Journal of Consulting and Clinical Psychology (1). Postdischarge from inpatient psychiatry is the highest risk period for suicide. The majority of deaths by suicide postdischarge happened within the […]

ESSSB20 symposium on the psychobiology of gender differences in suicidal behavior

Leo Sher, M.D. A large suicidology conference entitled “The 20th European Symposium on Suicide and Suicidal Behavior (ESSSB20)” took place on August 28-31, 2024, in the “Auditorium Della Tecnica” Convention Center in Rome, Italy. Prof. Dr. Marco Sarchiapone (Italy) was the President of the ESSSB20. The ESSSB20 Scientific Committee consisted of scholars from different countries […]

The influence of age on cortisol levels in depressed patients with and without comorbid post-traumatic stress disorder, and healthy volunteers

Leo Sher, M.D. Our research report, “Age effects on cortisol levels in depressed patients with and without comorbid post-traumatic stress disorder, and healthy volunteers” was published 20 years ago in the October 2004 issue of the Journal of Affective Disorders (1). In this study we focused on age, as an important variable that affects hypothalamic-pituitary-adrenal […]

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